Trixie Sango is the most popular girl in school, the leader of the cheerleader squad and the Ghostface killer in Scream 5. She is the sister of Jamie Sango. She was killed by Hayley McDonald, but she somehow survived. She was killed by Lauren Malloy but she survived.
- MCDONALD, WHERE ARE YOU? I AM GO TO FUCKING KILL YOU! (when Trixie shout and look for Hayley and Brooke)