Scream 21 takes place after Scream 20, Fifi is taken to the hospital after she was found by the 2 teenagers and she is put in the same room as Hayley who is recovering from a broken leg, she suffered when she was fighting with Lauren who had attacked her, she stabbed Hayley in back and thought she had died but recently just found out she was still alive. Thomas was worried about Lauren is come for Hayley that is why there were police guards outside her hospital room. Can Thomas, Sidney, Hayley, Jessica, Ethan and Fifi stop Lauren as Ghostface this time.




  • Keanu Reeves as Thomas Connor
  • Georgie Henley as Hayley McDonald/Lauren Malloy
  • Neve Campbell as Sidney Prescott
  • Matthew Lillard as Det Sam Macher
  • Emma Bell as Fifi Mone
  • Meagan Tandy as Denisha Jansen
  • Matthew Knight as Ethan Carsia
  • Amber Heard as Jessica Mitchell
  • Hart Turner as Tom Bennett
  • Jennifer Carpenter as Alyssa Hendricks
  • Tristen Wilds as Brian Olson
  • Jessica Lowndes as Rebecca Paulsen


Lauren Malloy-She


Thomas Connor

Hayley McDonald

Sidney Prescott

Det. Sam Macher

Fifi Mone

Ethan Carsia

Jessica Mitchell


Rebecca Paulsen-

Brian Olson-

Alyssa Hendricks-

Tom Bennett-

Police Guards-

Denisha Jansen-

Lauren Malloy-


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