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Orphan: The Return of Esther Coleman is horror film
- AnnaSophia Robb as Hermione McDonnell/The main character and Esther's half sister
- Ellen Wroe as Lucy Coleman/Esther's former foster sister
- Keke Palmer as Hallie Jones/Hermione's best friend and Esther former foster sister
- Emma Stone as Roxanne Nightingale/Esther's new sister
- Isabelle Furham as Esther Nightingale-Sissy-Jones-Coleman, a.k.a Leena Klammer-McDonnell/The killler and Hermione's half sister
- Rene Russo as Rachel Klammer/Esther and Hermione's mother
- Vera Farmiga as Kate Coleman/Lucy, Daniel and Max's mom
- Jimmy Bennett as Daniel Coleman/Kate's son
- Aryana Engineer as Max Coleman/Kate's daughter
- Amber Heard as Bea Sissy/Hermione's goth friend and Esther's former foster sister
- Jaden Smith as Fredro Jones/Hallie's brother
- Willow Smith as Saria Jones/Halle's sister